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Obesity

 

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US Obesity Epidemic

Obesity is a disease that has been increasing at an alarming rate with significant medical repercussions and associated economic costs. Currently, in the United States nearly 77 percent of females and more than 80 percent of males aged 15 and older are estimated to be overweight or obese (BMI ≥ 25 kg/m²), according to the World Health Organization. Many people with obesity also have severe and complex problems related to their disease, including metabolic and cardiovascular co-morbidities such as type 2 diabetes and hypertension.

Obesity is a complex disease and, for many, a lifelong challenge involving physiologic, behavioral, environmental and genetic factors, making it a difficult health issue to address. Many people with obesity struggle to reach and stay at a healthy weight following a seemingly endless challenge and failure of diet and exercise. Pharmaceutical options, while less invasive, can be associated with serious safety concerns, including cardiac and adverse side-effects, and are frequently less effective for morbidly obese patients. Bariatric surgery is more invasive, results in anatomical disfigurement, and may require frequent invasive adjustments or re-operation. It can involve major lifestyle changes, dietary restrictions and nutritional deficiencies. Only about one percent of people with obesity undergo bariatric surgery to address their condition.

Unmet Need

Given the limitations of transient and punitive procedures for the treatment of obesity, there continues to be a significant unmet need for a positive and more encouraging option…specifically:

  • A physiologic obesity treatment that helps patients succeed in their efforts to lose weight and keep it off, while controlling the co-morbidities of their obesity

  • A treatment that works with the body and allows patients to meet the significant behavioral, lifestyle and social challenges of obesity and weight loss in a flexible and private manner if desired

  • An option that does not require compromises in safety, nutrition, lifestyle, food choices or anatomy

  • A safe and sustainable solution that patients find acceptable and to which they can commit for the long term

  • A healthy new approach that will lead more patients to take that important step toward beating obesity with more lasting weight loss effects